SOCS1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
Immunogen
A synthetic peptide corresponding to N-terminus 17 amino acids of human SOCS1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of SOCS1 in human spleen tissue lysate with SOCS1 polyclonal antibody (Cat # PAB13192) at (A) 1, (B) 2 and (C) 4 ug/mL . -
Gene Info — SOCS1
Entrez GeneID
8651Protein Accession#
CAB92528Gene Name
SOCS1
Gene Alias
CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Gene Description
suppressor of cytokine signaling 1
Omim ID
603597Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
Other Designations
JAK binding protein|STAT induced SH3 protein 1|Tec-interacting protein 3|cytokine-inducible SH2 protein 1
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Pathway
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Publication Reference
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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, Crack PJ, Nicholson SE, Hilton DJ, O'Neill LA, Hertzog PJ.
Nature Immunology 2006 Feb; 7(2):148.
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The SOCS box: a tale of destruction and degradation.
Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ.
Trends in Biochemical Sciences 2002 May; 27(5):235.
Application:IHC, WB-Tr, Human, Mammalian cells.
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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.
O'Shea JJ, Gadina M, Schreiber RD.
Cell 2002 Apr; 109 Suppl:S121.
Application:WB, Human, Mouse, Mammalian cells.
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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
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