STRADB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of STRADB in human brain lysate with STRADB polyclonal antibody (Cat # PAB13114) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of STRADB in human brain tissue with STRADB polyclonal antibody (Cat # PAB13114) at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STRADB.
Immunogen
A synthetic peptide corresponding to internal region of human STRADB.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of STRADB in human brain lysate with STRADB polyclonal antibody (Cat # PAB13114) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of STRADB in human brain tissue with STRADB polyclonal antibody (Cat # PAB13114) at 10 ug/mL . -
Gene Info — STRADB
Entrez GeneID
55437Protein Accession#
NP_061041Gene Name
STRADB
Gene Alias
ALS2CR2, CALS-21, ILPIP, ILPIPA, MGC102916, PAPK, PRO1038
Gene Description
STE20-related kinase adaptor beta
Omim ID
607333Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. [provided by RefSeq
Other Designations
ILP-interacting protein ILPIPA|STRAD beta|amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2|pseudokinase ALS2CR2
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Interactome
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Publication Reference
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Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase.
Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind JS, Teramoto H, Ruscetti S.
The Journal of Biological Chemistry 2003 Apr; 278(15):13520.
Application：WB-Ce, Mouse, C19, HCD57, NIH/3T3 cells.
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ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis.
Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ.
The Journal of Biological Chemistry 2002 Jun; 277(34):30454.
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Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP.
Sanna MG, Duckett CS, Richter BW, Thompson CB, Ulevitch RJ.
PNAS 1998 May; 95(11):6015.
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Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase.
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