Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

STRADB

Gene Alias

ALS2CR2, CALS-21, ILPIP, ILPIPA, MGC102916, PAPK, PRO1038

Gene Description

STE20-related kinase adaptor beta

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. [provided by RefSeq

Other Designations

ILP-interacting protein ILPIPA|STRAD beta|amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2|pseudokinase ALS2CR2