ANTXR1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of ANTXR1 in K-562 cell lysates with ANTXR1 polyclonal antibody (Cat # PAB13110) at (A) 0.5, (B) 1, and (C) 2 ug/mL .
Immunocytochemistry
Immunocytochemistry of ANTXR1 in K-562 cells with ANTXR1 polyclonal antibody (Cat # PAB13110) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ANTXR1.
Immunogen
A synthetic peptide corresponding to C-terminus13 amino acids of human ANTXR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
ATR will recognize only the largest isoform.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ANTXR1 in K-562 cell lysates with ANTXR1 polyclonal antibody (Cat # PAB13110) at (A) 0.5, (B) 1, and (C) 2 ug/mL .Immunocytochemistry
Immunocytochemistry of ANTXR1 in K-562 cells with ANTXR1 polyclonal antibody (Cat # PAB13110) at 2 ug/mL . -
Gene Info — ANTXR1
Entrez GeneID
84168Protein Accession#
NP_444262Gene Name
ANTXR1
Gene Alias
ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Gene Description
anthrax toxin receptor 1
Omim ID
606410Gene Ontology
HyperlinkGene Summary
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
2310008J16Rik|2810405N18Rik|tumor endothelial marker 8
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Interactome
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Publication Reference
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Identification of the cellular receptor for anthrax toxin.
Bradley KA, Mogridge J, Mourez M, Collier RJ, Young JA.
Nature 2001 Nov; 414(6860):225.
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Cell surface tumor endothelial markers are conserved in mice and humans.
Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B.
Cancer Research 2001 Sep; 61(18):6649.
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Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.
Duesbery NS, Webb CP, Leppla SH, Gordon VM, Klimpel KR, Copeland TD, Ahn NG, Oskarsson MK, Fukasawa K, Paull KD, Vande Woude GF.
Science 1998 May; 280(5364):734.
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Identification of the cellular receptor for anthrax toxin.
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