ANTXR1 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
ANTXR1 polyclonal antibody (Cat # PAB6677) staining (0.3 ug/mL) of human PBMC lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ANTXR1.
Immunogen
A synthetic peptide corresponding to human ANTXR1.
Sequence
C-RAPPPSRPPPRPSV
Host
Goat
Theoretical MW (kDa)
62.8
Reactivity
Human
Specificity
This antibody is expected to recognize variant 1 (NP_115584) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.2-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
ANTXR1 polyclonal antibody (Cat # PAB6677) staining (0.3 ug/mL) of human PBMC lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ANTXR1
Entrez GeneID
84168Protein Accession#
NP_115584Gene Name
ANTXR1
Gene Alias
ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Gene Description
anthrax toxin receptor 1
Omim ID
606410Gene Ontology
HyperlinkGene Summary
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
2310008J16Rik|2810405N18Rik|tumor endothelial marker 8
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