IKBKG polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IKBKG.
Immunogen
A synthetic peptide corresponding to amino acids 400-416 of human IKBKG.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
The antigen used are identical to those of mouse homologue. A 52 KDa band should be detected. IKK gamma has no cross response to IKK alpha or IKK beta.
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IKBKG in HeLa whole cell lysate with IKBKG polyclonal antibody (Cat # PAB12856) at 1 ug/mL .Immunocytochemistry
Immunocytochemistry of IKBKG in HeLa cells with IKBKG polyclonal antibody (Cat # PAB12856) at 5 ug/mL . -
Gene Info — IKBKG
Entrez GeneID
8517Protein Accession#
AF074382Gene Name
IKBKG
Gene Alias
AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene Ontology
HyperlinkGene Summary
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [supplied by RefSeq
Other Designations
NFkappaB essential modulator|OTTHUMP00000026027|OTTHUMP00000026028|OTTHUMP00000026029|incontinentia pigmenti
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Interactome
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Pathway
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Disease
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Publication Reference
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IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.
Mercurio F, Murray BW, Shevchenko A, Bennett BL, Young DB, Li JW, Pascual G, Motiwala A, Zhu H, Mann M, Manning AM.
Molecular and Cellular Biology 1999 Feb; 19(2):1526.
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Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.
Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS.
PNAS 1999 Feb; 96(3):1042.
Application:IF, Mouse, C3HA cells.
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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
Rothwarf DM, Zandi E, Natoli G, Karin M.
Nature 1998 Sep; 395(6699):297.
Application:IP, WB-Tr, Human, Insect, Sf9, 293 cells.
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IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.
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