IKBKB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IKBKB.
Immunogen
A synthetic peptide corresponding to C-terminus of human IKBKB.
Host
Rabbit
Reactivity
Human
Specificity
Sequence differs from corresponding murine sequence by one amino acid. A 87 KDa band should be detected. This polyclonal antibody has no cross response to IKKa or IKKy.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IKBKB in Jurkat whole cell lysate with IKBKB polyclonal antibody (Cat # PAB12836) at 1 : 500 dilution.Immunocytochemistry
Immunocytochemistry staining of HeLa cells using IKBKB polyclonal antibody (Cat # PAB12836) at 10 ug/mL . -
Gene Info — IKBKB
Entrez GeneID
3551Protein Accession#
O14920Gene Name
IKBKB
Gene Alias
FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Omim ID
603258Gene Ontology
HyperlinkGene Summary
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
Other Designations
inhibitor of nuclear factor kappa B kinase beta subunit|nuclear factor NF-kappa-B inhibitor kinase beta
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Interactome
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Pathway
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Disease
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Publication Reference
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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV.
Science 1997 Oct; 278(5339):866.
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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M.
Nature 1997 Aug; 388(6642):548.
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Identification and characterization of an IkappaB kinase.
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M.
Cell 1997 Jul; 90(2):373.
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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
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