IKBKB recombinant monoclonal antibody, clone R01-9H6
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More Files
- More Functions
Western Blot
Western Blot analysis of 3T3 lysates with IKBKB recombinant monoclonal antibody, clone R01-9H6 (Cat # RAB02178).
Immunocytochemistry
Immunocytochemical staining of U87-MG with IKBKB recombinant monoclonal antibody, clone R01-9H6 (Cat # RAB02178). (A) IKBKB (green) and (B) DAPI (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human IKBKB.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human IKBKB.
Theoretical MW (kDa)
Calculated MW: 87 kD
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence(1:50-1:200)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at -20 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of 3T3 lysates with IKBKB recombinant monoclonal antibody, clone R01-9H6 (Cat # RAB02178).Immunocytochemistry
Immunocytochemical staining of U87-MG with IKBKB recombinant monoclonal antibody, clone R01-9H6 (Cat # RAB02178). (A) IKBKB (green) and (B) DAPI (blue).Immunofluorescence
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Gene Info — IKBKB
Entrez GeneID
3551Protein Accession#
O14920Gene Name
IKBKB
Gene Alias
FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Omim ID
603258Gene Ontology
HyperlinkGene Summary
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
Other Designations
inhibitor of nuclear factor kappa B kinase beta subunit|nuclear factor NF-kappa-B inhibitor kinase beta
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Interactome
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Pathway
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Disease
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