SOCS2 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The tissue lysates derived from mouse liver (Lane 1), mouse muscle (Lane 2) were immunoprobed by SOCS2 polyclonal antibody (Cat # PAB12779) at 1 : 500. An immunoreactive band is observed around ~23kDa.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SOCS2.
Immunogen
A synthetic peptide corresponding to C-terminus of human, mouse and rat SOCS2.
Host
Rabbit
Theoretical MW (kDa)
23
Reactivity
Human, Mouse
Specificity
This antibody recognizes ~23 KDa of SOCS2.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
The tissue lysates derived from mouse liver (Lane 1), mouse muscle (Lane 2) were immunoprobed by SOCS2 polyclonal antibody (Cat # PAB12779) at 1 : 500. An immunoreactive band is observed around ~23kDa.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SOCS2
Entrez GeneID
8835Gene Name
SOCS2
Gene Alias
CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2
Gene Description
suppressor of cytokine signaling 2
Omim ID
605117Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq
Other Designations
STAT induced STAT inhibitor-2|cytokine-inducible SH2 protein 2|suppressor of cytokine signaling-2
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Gene Info — Socs2
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Gene Info — Socs2
Entrez GeneID
216233Gene Name
Socs2
Gene Alias
8030460M17, AI527257, AW108012, CIS2, Cish2, D130043N08Rik, JAB, MGC118106, SOCS-2, SSI-2, hg
Gene Description
suppressor of cytokine signaling 2
Gene Ontology
HyperlinkOther Designations
STAT-induced STAT inhibitor 2|cytokine inducible SH2-containing protein 2|cytokine-inducible SH2 protein 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.
Dey BR, Spence SL, Nissley P, Furlanetto RW.
The Journal of Biological Chemistry 1998 Sep; 273(37):24095.
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Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.
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