The 4 mg protein of whole tissue lysates derived from human brain were immunoprecipitated by 4 ug of NRP1 polyclonal antibody (Cat # PAB12718) o/n at 4°C, and probed by the same antibody at 1 : 1000. An immunoreactive band at ~130kDa was observed.
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM