GSK3A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
The NIH/3T3 cell lysate was resolved onto 10% SDS-PAGE, transferred onto NC membrane, and followed by an immunoblotting with GSK3A polyclonal antibody (Cat # PAB12687) at 1 : 500 (lane 1). Lane 2 was pre-incubated with immunizing peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GSK3A.
Immunogen
A synthetic peptide corresponding to N-terminus of human GSK3A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody recognizes GSK3A.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In TBS, pH 7.2 (BSA, 10% Proclin300)
Storage Instruction
Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
The NIH/3T3 cell lysate was resolved onto 10% SDS-PAGE, transferred onto NC membrane, and followed by an immunoblotting with GSK3A polyclonal antibody (Cat # PAB12687) at 1 : 500 (lane 1). Lane 2 was pre-incubated with immunizing peptide.Immunohistochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — GSK3A
Entrez GeneID
2931Gene Name
GSK3A
Gene Alias
DKFZp686D0638
Gene Description
glycogen synthase kinase 3 alpha
Omim ID
606784Gene Ontology
HyperlinkGene Summary
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.
Asuni AA, Hooper C, Reynolds CH, Lovestone S, Anderton BH, Killick R.
The European Journal of Neuroscience 2006 Dec; 24(12):3387.
Application：WB, Mouse, CHO cells.
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Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T.
The Journal of Biological Chemistry 2004 Nov; 279(46):47720.
Application：WB, Mouse, Mouse bone marrow-derived mast cells.
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GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.
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