EGLN1 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of EGLN1 using EGLN1 polyclonal antibody (Cat # PAB12440). Samples : Recombinant FLAG-His-EGLN2, EGLN1 and EGLN3 (10 ng/lane), HeLa whole cell lysate and MEF.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EGLN1.
Immunogen
A synthetic peptide corresponding to amino acids 350-426 of human EGLN1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to human HIF prolyl hydroxylase 2. There is 83% homology between the immunogen used for this antibody and the rat and mouse proteins.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of EGLN1 using EGLN1 polyclonal antibody (Cat # PAB12440). Samples : Recombinant FLAG-His-EGLN2, EGLN1 and EGLN3 (10 ng/lane), HeLa whole cell lysate and MEF.Immunohistochemistry
Immunoprecipitation
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Gene Info — EGLN1
Entrez GeneID
54583Protein Accession#
Q9GZT9Gene Name
EGLN1
Gene Alias
C1orf12, DKFZp761F179, ECYT3, HIFPH2, HPH2, PHD2, SM-20, SM20, ZMYND6
Gene Description
egl nine homolog 1 (C. elegans)
Gene Ontology
HyperlinkOther Designations
HIF prolyl hydroxylase 2|egl nine homolog 1|egl nine-like protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.
Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD.
Science Signaling 2008 Dec; 1(51):ra18.
Application：WB, Human, HEK 293 cells.
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The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis.
Colla S, Tagliaferri S, Morandi F, Lunghi P, Donofrio G, Martorana D, Mancini C, Lazzaretti M, Mazzera L, Ravanetti L, Bonomini S, Ferrari L, Miranda C, Ladetto M, Neri TM, Neri A, Greco A, Mangoni M, Bonati A, Rizzoli V, Giuliani N.
Blood 2007 Dec; 110(13):4464.
Application：WB-Tr, Human, JJN3 cells.
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Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I.
Biology of Reproduction 2006 Jul; 75(1):112.
Application：WB-Ti, Human, Human placentae.
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OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL.
Molecular Cell 2005 Feb; 17(4):503.
Application：IP, WB-Tr, Human, HEK 293 cells.
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mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.
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