Western Blot analysis of CUL4B expression from cell and tissue extracts with CUL4B polyclonal antibody (Cat # PAB12320). Lane 1 : female zebrafish tissue lysate. Lane 2 : MM453 whole cell lysate. Lane 3 : rat liver tissue lysate. Lane 4 : rat lung tissue lysate. Lane 5 : MCF-7 whole cell lysate. Lane 6 : MM231 whole cell lysate.
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq