ANGPT2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ANGPT2.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human ANGPT2.
Host
Rabbit
Theoretical MW (kDa)
57
Reactivity
Human, Rat
Specificity
Different from the related mouse sequence by two amino acids.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of ANGPT2 expression from rat brain tissue lyate with ANGPT2 polyclonal antibody (Cat # PAB12280). -
Gene Info — ANGPT2
Entrez GeneID
285GeneBank Accession#
AB009865Protein Accession#
BAA95590Gene Name
ANGPT2
Gene Alias
AGPT2, ANG2
Gene Description
angiopoietin 2
Omim ID
601922Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Tie2-ligand|angiopoietin-2|angiopoietin-2B|angiopoietin-2a
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Interactome
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Disease
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Publication Reference
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Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2.
Ward EG, Grosios K, Markham AF, Jones PF.
Cytogenetics and Cell Genetics 2001 Dec; 94(3-4):147.
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Characterization and expression of a novel alternatively spliced human angiopoietin-2.
Kim I, Kim JH, Ryu YS, Jung SH, Nah JJ, Koh GY.
The Journal of Biological Chemistry 2000 Jun; 275(24):18550.
Application:WB-Ce, Human, C33A, CaSki cells, HUVECs.
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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD.
Science 1997 Jul; 277(5322):55.
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Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2.
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