CUL4A polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CUL4A.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 1-20 of human CUL4A.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000-1:10000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining with CUL4A polyclonal antibody (Cat # PAB10038) was diluted 1 : 500 to detect CUL4 in human testis tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CUL4A
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Interactome
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Pathway
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Publication Reference
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ESCCAL-1 promotes cell-cycle progression by interacting with and stabilizing galectin-1 in esophageal squamous cell carcinoma.
Yuanbo Cui, Ming Yan, Wei Wu, Pengju Lv, Jinwu Wang, Yanping Huo, Yanan Lou, Xiwen Ma, Jing Chang, Fangxia Guan, Wei Cao.
NPJ Precision Oncology 2022 Mar; 6(1):12.
Application:WB-Tr, Human, KYSE450 cells.
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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y.
Cell 2003 May; 113(3):357.
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CUL-4A is critical for early embryonic development.
Li B, Ruiz JC, Chun KT.
Molecular and Cellular Biology 2002 Jul; 22(14):4997.
Application:WB-Ce, Human, PLB-985 cells.
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Cullin 4A associates with the UV-damaged DNA-binding protein DDB.
Shiyanov P, Nag A, Raychaudhuri P.
The Journal of Biological Chemistry 1999 Dec; 274(50):35309.
Application:WB-Ce, WB-Tr, Human, HeLa, U-2 OS cells.
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ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.
Ohta T, Michel JJ, Schottelius AJ, Xiong Y.
Molecular Cell 1999 Apr; 3(4):535.
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Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
Michel JJ, Xiong Y.
Cell Growth & Differentiation: the Molecular Biology Journal of the American Association for Cancer 1998 Jun; 9(6):435.
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ESCCAL-1 promotes cell-cycle progression by interacting with and stabilizing galectin-1 in esophageal squamous cell carcinoma.
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