Western blot detection of human SOD1 using rabbit SOD1 polyclonal antibody (Cat # PAB0724) at a dilution of 1 in 500. This antibody detects a band of 16 KDa in human Jurkat T cell extracts (lane 2) . Its specificity for human SOD1 is shown by the lack of reactivity with mouse brain tissue extracts (lane 1) .
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq
Cu /Zn superoxide dismutase,Cu/Zn superoxide dismutase,SOD, soluble,indophenoloxidase A,superoxide dismutase, cystolic