TRAF2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRAF2.
Immunogen
A synthetic peptide corresponding to amino acids 87-106 of human TRAF2.
Sequence
SSSAFPDNAARREVESLPAV
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunhistochemical analysis of TRAF2 in formalin-fixed, paraffin-embedded normal human bone marrow section using TRAF2 polyclonal antibody (Cat # PAB0275) at 1 : 2000. Hematoxylin-eosin counterstain.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunhistochemical analysis of TRAF2 in formalin-fixed, paraffin-embedded normal human thymus sections using TRAF2 polyclonal antibody (Cat # PAB0275) at 1 : 2000. A-C, successively higher magnifications. Hematoxylin-eosin counterstain.Immunoprecipitation
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Gene Info — TRAF2
Entrez GeneID
7186Gene Name
TRAF2
Gene Alias
MGC:45012, TRAP, TRAP3
Gene Description
TNF receptor-associated factor 2
Omim ID
601895Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq
Other Designations
OTTHUMP00000022625|OTTHUMP00000064745|tumor necrosis factor type 2 receptor associated protein 3
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