Western blot analysis of MALT1 expression. Using MALT1 polyclonal antibody (Cat # PAB0270) at 1 : 2000. HEK293N cells transiently transfected with control (empty) plasmid (Ctl-) or human full-length MALT1 (Ctl+) were used as negative or positive controls, respectively. Freshly isolated human polymorphonuclear neutrophils (PMN) and resting B-cells were negative. MALT1 expression was detected in SKW64, Ramos, and BJAB B-cell lymphoma lines, and 3 out of 6 B-cell chronic lymphocytic luekemia (CLL) patients.
Immunohistochemical analysis of MALT1 expression in formalin-fixed human reactive lymph node. Using MALT1 polyclonal antibody (Cat # PAB0270) at 1 : 2000. A. Low magnification. A1-3, high magnification from A : A1, mantle zone. A2, germinal center. A3. marginal zone. Hematoxylin-eosin counterstain.
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq