MALT1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant MALT1.
Immunogen
Recombinant protein corresponding to full length human MALT1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum (0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of MALT1 expression. Using MALT1 polyclonal antibody (Cat # PAB0270) at 1 : 2000. HEK293N cells transiently transfected with control (empty) plasmid (Ctl-) or human full-length MALT1 (Ctl+) were used as negative or positive controls, respectively. Freshly isolated human polymorphonuclear neutrophils (PMN) and resting B-cells were negative. MALT1 expression was detected in SKW64, Ramos, and BJAB B-cell lymphoma lines, and 3 out of 6 B-cell chronic lymphocytic luekemia (CLL) patients.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of MALT1 expression in formalin-fixed human reactive lymph node. Using MALT1 polyclonal antibody (Cat # PAB0270) at 1 : 2000. A. Low magnification. A1-3, high magnification from A : A1, mantle zone. A2, germinal center. A3. marginal zone. Hematoxylin-eosin counterstain.Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — MALT1
Entrez GeneID
10892Gene Name
MALT1
Gene Alias
DKFZp434L132, MLT, MLT1
Gene Description
mucosa associated lymphoid tissue lymphoma translocation gene 1
Omim ID
604860Gene Ontology
HyperlinkGene Summary
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
MALT associated translocation|MALT-lymphoma associated translocation|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation protein 1|paracaspase
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Interactome
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Disease
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