TNFRSF9 (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF9 (Q07011, 18 a.a. - 184 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
TRSLQDPCSNCPAGTFCDNNRNQICSPCPPNSFSSAGGQRTCDICRQCKGVFRTRKECSSTSNAECDCTPGFHCLGAGCSMCEQDCKQGQELTKKGCKDCCFGTFNDQKRGICRPWTNCSLDGKSVLVNGTKERDVVCGPSPADLSPGASSVTPPAPAREPGHS
Host
Escherichia coli
Theoretical MW (kDa)
17.7
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 97% as analyzed by SDS-PAGE.
> 97% as analyzed by HPLC.Endotoxin Level
< 1 EU/ug of protein by LAL method
Activity
Fully biologically active compared to the standard. The biological activity is determined by the inhibitory effect on IL-8 production using human peripheral blood mononuclear cells. At a concentration of 1.0 ug for both the 4-1BB ligand and the 4-1BB receptor, an inhibition of approximately 90 % was observed.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS. Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL.
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — TNFRSF9
Entrez GeneID
3604Protein Accession#
Q07011Gene Name
TNFRSF9
Gene Alias
4-1BB, CD137, CDw137, ILA, MGC2172
Gene Description
tumor necrosis factor receptor superfamily, member 9
Omim ID
602250Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq
Other Designations
4-1BB ligand receptor|CD137 antigen|OTTHUMP00000001360|OTTHUMP00000044294|T cell antigen ILA|homolog of mouse 4-1BB|induced by lymphocyte activation (ILA)|interleukin-activated receptor, homolog of mouse Ly63|receptor protein 4-1BB
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Interactome
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Disease
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