IL13 (Human) Recombinant Protein
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Specification
Product Description
Human IL13 (P35225, 33 a.a. - 146 a.a.) partial recombinant protein expressed in CHO cells.
Sequence
SPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN
Host
Mammals
Theoretical MW (kDa)
25 ~ 45
Form
Lyophilized
Preparation Method
Mammalian cell (CHO) expression system_x005F_x000D__x000D_
Purity
> 95% as analyzed by SDS-PAGE.
Endotoxin Level
< 0.2 EU/ ug of protein (gel clotting method)
Activity
ED50 < 15.0 ng/mL, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 6.7 × 105 units/mg.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS. Reconstitute the lyophilized powder in ddH2O up to 100 ug/mL.
Storage Instruction
Store at 4°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IL13
Entrez GeneID
3596Protein Accession#
P35225Gene Name
IL13
Gene Alias
ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600
Gene Description
interleukin 13
Gene Ontology
HyperlinkGene Summary
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq
Other Designations
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