IL3RA (Human) Recombinant Protein
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Specification
Product Description
Human IL3RA (NP_002174.1, 20 a.a. - 305 a.a.) partial recombinant protein with His tag at C-terminus expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
145-150
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 90% by SDS-PAGE
Endotoxin Level
< 0.1 EU/ug
Activity
Measured by the binding ability in a functional ELISA. Immobilized recombinant Human IL3 at 4 ug/mL (100 uL/well) can bind recombinant Human IL3RA, the EC50 of Human IL3RA is 5.3 ug/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
IL3RA (Human) Recombinant Protein (Cat #P6767) was determined by SDS-PAGE with Coomassie Blue, showing a band at 145-150kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — IL3RA
Entrez GeneID
3563Protein Accession#
P26951Gene Name
IL3RA
Gene Alias
CD123, IL3R, IL3RAY, IL3RX, IL3RY, MGC34174, hIL-3Ra
Gene Description
interleukin 3 receptor, alpha (low affinity)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. [provided by RefSeq
Other Designations
CD123 antigen|Interleukin-3 receptor|OTTHUMP00000022828|interleukin 3 receptor, alpha
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