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KLRC1/KLRD1 (Human) Recombinant Protein BioActive

  • Catalog # : P6742
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  • Specification
  • Product Description:
  • Human KLRC1/KLRD1 (100 a.a. - 233 a.a./34 a.a. - 179 a.a.) partial recombinant protein with a mFc tag at the C-terminus expressed in Expi293 cells.
  • Host:
  • Human
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (Expi293) expression system
  • Purification:
  • Protein A purification
  • Purity:
  • > 95% (determined by Tris-Bis PAGE)
  • Endotoxin Level:
  • < 1 EU/ug of protein (determined by LAL method)
  • Activity:
  • Immobilized human KLRC1/KLRD1, His tag at 0.5 ug/mL (100 uL/well). Dose response curve for Anti-KLRC1/KLRD1 Ab with the EC50 of 0.2 ug/mL determined by ELISA.
  • Quality Control Testing:
  • Tris-Bis PAGE under reduced condition.

    QC Testing of P6742
  • Recommend Usage:
  • Tris-Bis PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
  • Storage Instruction:
  • Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Conformation:
  • Heterodimer
  • Applications
  • Immunogen
  • SDS-PAGE
  • Application Image
  • Immunogen
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3821
  • Protein Accession#:
  • P26715;Q13241
  • Gene Name:
  • KLRC1
  • Gene Alias:
  • CD159A,MGC13374,MGC59791,NKG2,NKG2A
  • Gene Description:
  • killer cell lectin-like receptor subfamily C, member 1
  • Gene Summary:
  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq
  • Other Designations:
  • C-lectin type II protein,NK cell receptor A,NKG2-1/B activating NK receptor,NKG2-A/B type II integral membrane protein,natural killer cell lectin,natural killer group protein 2
  • Gene Information
  • Entrez GeneID:
  • 3824
  • Protein Accession#:
  • P26715;Q13241
  • Gene Name:
  • KLRD1
  • Gene Alias:
  • CD94
  • Gene Description:
  • killer cell lectin-like receptor subfamily D, member 1
  • Gene Summary:
  • Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD94 antigen
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