KLRC1/KLRD1 (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
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Specification
Product Description
Human KLRC1/KLRD1 (100 a.a. - 233 a.a./34 a.a. - 179 a.a.) partial recombinant protein with a mFc tag at the C-terminus expressed in Expi293 cells.
Host
Human
Form
Lyophilized
Preparation Method
Mammalian cell (Expi293) expression system
Purification
Protein A purification
Purity
> 95% (determined by Tris-Bis PAGE)
Endotoxin Level
< 1 EU/ug of protein (determined by LAL method)
Activity
Immobilized human KLRC1/KLRD1, His tag at 0.5 ug/mL (100 uL/well). Dose response curve for Anti-KLRC1/KLRD1 Ab with the EC50 of 0.2 ug/mL determined by ELISA.
Quality Control Testing
Tris-Bis PAGE under reduced condition.
Recommend Usage
Tris-Bis PAGE
The optimal working dilution should be determined by the end user.Conformation
Heterodimer
Storage Buffer
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Storage Instruction
Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — KLRC1
Entrez GeneID
3821Protein Accession#
P26715;Q13241Gene Name
KLRC1
Gene Alias
CD159A, MGC13374, MGC59791, NKG2, NKG2A
Gene Description
killer cell lectin-like receptor subfamily C, member 1
Omim ID
161555Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq
Other Designations
C-lectin type II protein|NK cell receptor A|NKG2-1/B activating NK receptor|NKG2-A/B type II integral membrane protein|natural killer cell lectin|natural killer group protein 2
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Gene Info — KLRD1
Entrez GeneID
3824Protein Accession#
P26715;Q13241Gene Name
KLRD1
Gene Alias
CD94
Gene Description
killer cell lectin-like receptor subfamily D, member 1
Omim ID
602894Gene Ontology
HyperlinkGene Summary
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD94 antigen
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Interactome
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Pathway
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Disease
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