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IL17A (Human) Recombinant ProteinBioActive

  • Catalog # : P3631
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  • Specification
  • Product Description:
  • Human IL17A (Q16552, 20 a.a. - 134 a.a.) partial recombinant protein expressed in Escherichia coli.
  • Sequence:
  • IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 16
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Purification:
  • Ion exchange column and HPLC reverse phase column
  • Purity:
  • > 90% by SDS-PAGE and HPLC
  • Endotoxin Level:
  • < 0.1 ng/ug (1 EU/ug)
  • Activity:
  • The ED50 was determined by the dose-dependent proliferation of induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/mL., corresponding to a specific activity of <5 x 105 units/mg.
  • Storage Buffer:
  • Lyophilized from PBS, pH 7.5
  • Storage Instruction:
  • Store at -20°C on dry atmosphere for 2 years.
    After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3605
  • Gene Name:
  • IL17A
  • Gene Alias:
  • CTLA8,IL-17,IL-17A,IL17
  • Gene Description:
  • interleukin 17A
  • Gene Summary:
  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000016597,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
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