PDGFRA monoclonal antibody, clone 16A1
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Specification
Product Description
Mouse monoclonal antibody raised against PDGFRA.
Immunogen
Human PDGFRA transfected NIH/3T3 cells.
Host
Mouse
Reactivity
Human
Specificity
This antibody is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.
Form
Liquid
Concentration
1 mg/mL
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunocytochemistry
Flow Cytometry
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Gene Info — PDGFRA
Entrez GeneID
5156Gene Name
PDGFRA
Gene Alias
CD140A, MGC74795, PDGFR2, Rhe-PDGFRA
Gene Description
platelet-derived growth factor receptor, alpha polypeptide
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq
Other Designations
FIP1L1/PDGFRA fusion protein|platelet-derived growth factor receptor alpha|rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo.
Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A.
Neoplasia 2009 Aug; 11(8):732.
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The PDGF signaling pathway controls multiple steroid-producing lineages.
Schmahl J, Rizzolo K, Soriano P.
Genes & Development 2008 Dec; 22(23):3255.
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Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function.
French WJ, Creemers EE, Tallquist MD.
Molecular and Cellular Biology 2008 Sep; 28(18):5646.
Application:IHC-Fr, WB-Ti, Mouse, Mouse embryo.
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Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo.
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