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SNCA monoclonal antibody

  • Catalog # : MAB8432
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against full length recombinant SNCA.
  • Immunogen:
  • Recombinant protein corresponding to full length human SNCA.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 15
  • Reactivity:
  • Human, Rat
  • Specificity:
  • This antibody has been directly tested for reactivity in human and rodent. It is expected that it will work on other mammal tissues. specific to the ~15KDa alpha Synuclein protein.
  • Form:
  • Liquid
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunofluorescence (1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In ascites (10 mM sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 1.
  • alpha-Synuclein locus triplication causes Parkinson's disease.
    Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K.Science. 2003 Oct 31;302(5646):841.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot of rat brain lysate showing specific immunolabeling ~ 15 kDa of SNCA protein. Using SNCA monoclonal antibody (Cat # MAB8432).
  • Immunofluorescence
  • Immunofluorescence
  • Mixed hyman neuron-glial cultures stained with SNCA (red) and chicken MAP2 (green). The SNCA monoclonal antibody (Cat # MAB8432) stains vesicular structures, the perikarya and processes of the neurons in this image.
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 6622
  • Gene Name:
  • SNCA
  • Gene Alias:
  • MGC110988,NACP,PARK1,PARK4,PD1
  • Gene Description:
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Gene Summary:
  • Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000161559,OTTHUMP00000161561,alpha synuclein,alpha-synuclein,alpha-synuclein, isoform NACP140,non A-beta component of AD amyloid,non A4 component of amyloid
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