SNCA monoclonal antibody, clone 2A7
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot of rat brain lysate showing specific immunolabeling ~ 15 kDa of SNCA protein. Using SNCA monoclonal antibody (Cat # MAB8432).
Immunofluorescence
Immunofluorescence of rat cerebellum showing specific alpha-synuclein staining in synaptic regions in red and GFAP in the cytoskeleton of glia and astrocytes in green. DNA is stained blue.
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant SNCA.
Immunogen
Recombinant protein corresponding to full length human SNCA.
Host
Mouse
Theoretical MW (kDa)
15
Reactivity
Human, Rat
Specificity
This antibody has been directly tested for reactivity in human and rodent. It is expected that it will work on other mammal tissues. specific to the ~15KDa alpha Synuclein protein.
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunocytochemistry
Immunohistochemistr ( 1:1000)
Immunofluorescence (1:1000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 5 mM sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot of rat brain lysate showing specific immunolabeling ~ 15 kDa of SNCA protein. Using SNCA monoclonal antibody (Cat # MAB8432).Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Immunofluorescence of rat cerebellum showing specific alpha-synuclein staining in synaptic regions in red and GFAP in the cytoskeleton of glia and astrocytes in green. DNA is stained blue. -
Gene Info — SNCA
Entrez GeneID
6622Protein Accession#
P37840Gene Name
SNCA
Gene Alias
MGC110988, NACP, PARK1, PARK4, PD1
Gene Description
synuclein, alpha (non A4 component of amyloid precursor)
Gene Ontology
HyperlinkGene Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161559|OTTHUMP00000161561|alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid
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Interactome
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Disease
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Publication Reference
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alpha-Synuclein locus triplication causes Parkinson's disease.
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, Hardy J, Gwinn-Hardy K.
Science 2003 Oct; 302(5646):841.
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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein.
Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C.
The Journal of Biological Chemistry 2000 Jan; 275(1):390.
Application：WB-Ti, WB-Tr, Human, Brain, K293, PC12 cells.
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alpha-Synuclein locus triplication causes Parkinson's disease.
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