Mouse monoclonal antibody raised against recombinant NPM1.
Recombinant protein corresponding to human NPM1.
Western Blot (1:500-1:2000) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:2000) Immunohistochemistry (Frozen sections) (1:500-1:2000) ELISA (1:10000) The optimal working dilution should be determined by the end user.
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF (MIM 600160). NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia (AML; MIM 601626) (Garzon et al., 2008 [PubMed 18308931]).[supplied by OMIM
nucleolar phosphoprotein B23,nucleophosmin 1,nucleophosmin/nucleoplasmin family, member 1,numatrin