TNNI3 monoclonal antibody, clone 3A10A12, 5C3A7
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TNNI3.
Immunogen
Recombinant protein corresponding to truncated human TNNI3.
Host
Mouse
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:200-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:1000)
Immunohistochemistry (Frozen sections) (1:200-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using TNNI3 monoclonal antibody, clone 3A10A12, 5C3A7 (Cat # MAB8299) against truncated TNNI3 recombinant protein.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human normal cardiac muscle tissue showing cytoplasmic localization, using TNNI3 monoclonal antibody, clone 3A10A12, 5C3A7 (Cat # MAB8299) with DAB staining.Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNNI3
Entrez GeneID
7137Gene Name
TNNI3
Gene Alias
CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI
Gene Description
troponin I type 3 (cardiac)
Gene Ontology
HyperlinkGene Summary
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq
Other Designations
familial hypertrophic cardiomyopathy 7|troponin I, cardiac
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Interactome
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Pathway
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Disease
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Publication Reference
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Cardiac troponin I. A marker with high specificity for cardiac injury.
Adams JE 3rd, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS.
Circulation 1993 Jul; 88(1):101.
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New monoclonal antibodies as probes for human cardiac troponin I: epitopic analysis with synthetic peptides.
Larue C, Defacque-Lacquement H, Calzolari C, Le Nguyen D, Pau B.
Molecular Immunology 1992 Feb; 29(2):271.
Application:RIA, Mouse, Mouse serum, Peptides, Recombinant proteins.
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Cardiac specific troponin-I release in canine experimental myocardial infarction: development of a sensitive enzyme-linked immunoassay.
Cummins B, Cummins P.
Journal of Molecular and Cellular Cardiology 1987 Oct; 19(10):999.
Application:ELISA, Dog, Dog heart, Dog skeletal tissues.
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Cardiac troponin I. A marker with high specificity for cardiac injury.
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