Products

Western Blot

Western blot analysis of human heart lysate with TNNI3 recombinant monoclonal antibody, clone scFv 180 (Cat # RAB03118).

Immunofluorescence

Immunofluorescent staining of HeLa cells with TNNI3 recombinant monoclonal antibody, clone scFv 180 (Cat # RAB03118).
Immunofluorescence analysis of paraformaldehyde fixed HeLa cells permewith 0.15% Triton and stained with the chimeric mouse IgG1 version of RAB03118 at 10 ug/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/ml)- showing cytoplasmic staining. The nuclear stain is DAPI (blue). Panels show from left-right- top-bottom RAB03118- DAPI- merged channels and an isotype control. The isotype control was stained with an anti-unknown specificity antibody followed by Alexa Fluor® 488 secondary antibody.

Surface Plasmon Resonance

Entrez GeneID

7137

Gene Name

TNNI3

Gene Alias

CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI

Gene Description

troponin I type 3 (cardiac)

Omim ID

115210 191044

Gene Ontology

Hyperlink

Gene Summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq

Other Designations

familial hypertrophic cardiomyopathy 7|troponin I, cardiac