Western blot analysis from human cartilage with SOD3 monoclonal antibody, clone 4GG11G6 (Cat # MAB6644). Lane 1, recombinant SOD3 protein. Lane 2, human liver. Lane 3, human lung. Lane 4, human cartilage.
Immunohistochemical analysis of human cartilage with SOD3 monoclonal antibody, clone 4GG11G6 (Cat # MAB6644). Image A, control. Image B, young. Image C, cartilage with osterarthritis.
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq