SOD3 monoclonal antibody, clone 4GG11G6
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More Files
- More Functions
Western Blot
Western blot analysis from human cartilage with SOD3 monoclonal antibody, clone 4GG11G6 (Cat # MAB6644).
Lane 1, recombinant SOD3 protein.
Lane 2, human liver.
Lane 3, human lung.
Lane 4, human cartilage.
Immunohistochemistry
Immunohistochemical analysis of human cartilage with SOD3 monoclonal antibody, clone 4GG11G6 (Cat # MAB6644).
Image A, control.
Image B, young.
Image C, cartilage with osterarthritis.
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Specification
Product Description
Mouse monoclonal antibody raised against native SOD3.
Immunogen
Native purified SOD3 from human aortas.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
Detects EC SOD at ~35KDa.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:100)
Immunocytochemistry (1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis from human cartilage with SOD3 monoclonal antibody, clone 4GG11G6 (Cat # MAB6644).
Lane 1, recombinant SOD3 protein.
Lane 2, human liver.
Lane 3, human lung.
Lane 4, human cartilage.Immunohistochemistry
Immunohistochemical analysis of human cartilage with SOD3 monoclonal antibody, clone 4GG11G6 (Cat # MAB6644).
Image A, control.
Image B, young.
Image C, cartilage with osterarthritis.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SOD3
Entrez GeneID
6649Gene Name
SOD3
Gene Alias
EC-SOD, MGC20077
Gene Description
superoxide dismutase 3, extracellular
Omim ID
185490Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq
Other Designations
OTTHUMP00000158715
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Interactome
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Disease
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Publication Reference
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Extracellular superoxide dismutase and oxidant damage in osteoarthritis.
Regan E, Flannelly J, Bowler R, Tran K, Nicks M, Carbone BD, Glueck D, Heijnen H, Mason R, Crapo J.
Arthritis and Rheumatism 2005 Nov; 52(11):3479.
Application：IHC-P, S-ELISA, WB-Ti, Human, Articular cartilage.
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Synthesis and processing of the precursor for human mangano-superoxide dismutase.
Wispe JR, Clark JC, Burhans MS, Kropp KE, Korfhagen TR, Whitsett JA.
Biochimica et Biophysica Acta 1989 Jan; 994(1):30.
Application：IP, RIA, WB-Tr, Human, HepG2 cells, Rabbit reticulocytes.
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Biosynthesis and regulation of superoxide dismutases.
Hassan HM.
Free Radical Biology & Medicine 1988 Jan; 5(5-6):377.
Application：WB, Human, Plant, Rat, Yeast, Endothelial cells, Plant cells, Rat lung, Yeast cells.
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Extracellular superoxide dismutase and oxidant damage in osteoarthritis.
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