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Last updated: 2017/2/19
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XRCC5 monoclonal antibody, clone MEM-54

  • Catalog # : MAB6468
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native XRCC5.
  • Immunogen:
  • Native purified XRCC5 from human whole T-lymphocytes.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with Ku80, a 80 KDa subunit of Ku autoantigen (heterodimer of72 and 87 KDa polypeptides). Ku autoantigen is involved in DNA repair and in V(D) Jrecombination through its ability to bind DNA double-strand breaks.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Immunocytochemistry (2 ug/mL)
    Immunofluorescence
    Immunoprecipitation
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunocytochemistry
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence staining of HeLa (human cervix carcinoma cell line) using XRCC5 monoclonal antibody, clone MEM-54 (Cat # MAB6468) (detection by Goat anti-mouse IgG2a Alexa Fluor® 488 ; green).
    Actin (red) was stained with Phalloidin-TRITC, nuclei with DAPI (blue).
  • Immunoprecipitation
  • Application Image
  • Immunocytochemistry
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 7520
  • Gene Name:
  • XRCC5
  • Gene Alias:
  • FLJ39089,KARP-1,KARP1,KU80,KUB2,Ku86,NFIV
  • Gene Description:
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • Gene Summary:
  • The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
  • Other Designations:
  • ATP-dependent DNA helicase II,DNA repair protein XRCC5,Ku autoantigen, 80kDa,Ku86 autoantigen related protein 1,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD),X-ray repair, comp
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