HSPA4/HSPA8 monoclonal antibody, clone N27F3-4
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant HSPA4/HSPA8.
Immunogen
Recombinant protein corresponding to human HSPA4/HSPA8.
Host
Mouse
Reactivity
Bovine, Chicken, Dog, Fish, Frog, Fruit fly, Guinea pig, Hamster, Human, Monkey, Mouse, Nematoda, Pig, Plants, Rabbit, Rat, Sheep
Specificity
The epitope is in the region of amino acids 503-640 of human Hsp70.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (1-10 ug/mL)
Immunoprecipitation (1-10 ug/mL)
Flow cytometry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
Flow Cytometry
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Gene Info — HSPA4
Entrez GeneID
3308Gene Name
HSPA4
Gene Alias
APG-2, HS24/P52, MGC131852, RY, hsp70, hsp70RY
Gene Description
heat shock 70kDa protein 4
Omim ID
601113Gene Ontology
HyperlinkGene Summary
isoform a|heat shock protein
Other Designations
heat shock 70kD protein 4|heat shock 70kDa protein 4, isoform a|heat shock protein, 110 kDa
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Gene Info — HSPA8
Entrez GeneID
3312Gene Name
HSPA8
Gene Alias
HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, MGC131511, MGC29929, NIP71
Gene Description
heat shock 70kDa protein 8
Omim ID
600816Gene Ontology
HyperlinkGene Summary
The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. [provided by RefSeq
Other Designations
LPS-associated protein 1|N-myristoyltransferase inhibitor protein 71|constitutive heat shock protein 70|heat shock 70kD protein 8|heat shock 70kd protein 10|heat shock cognate protein 54|heat shock cognate protein, 71-kDa|lipopolysaccharide-associated pro
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Interactome
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Pathway
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Disease
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Publication Reference
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The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma.
Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R.
PLoS One 2014 Apr; 9(4):e92041.
Application:IHC-P, Human, Merkel cell carcinoma.
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The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma.
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