MAP2K4 monoclonal antibody, clone 2D10D8,4G11B2
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded lymphocyte of human thymoma and human spleen tissue showing cytoplasmic localization using MAP2K4 monoclonal antibody, clone 2D10D8,4G11B2 (Cat # MAB5532) with DAB staining.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant MAP2K4.
Immunogen
Recombinant protein corresponding to human MAP2K4.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgM
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded lymphocyte of human thymoma and human spleen tissue showing cytoplasmic localization using MAP2K4 monoclonal antibody, clone 2D10D8,4G11B2 (Cat # MAB5532) with DAB staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAP2K4
Entrez GeneID
6416Gene Name
MAP2K4
Gene Alias
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1
Gene Description
mitogen-activated protein kinase kinase 4
Omim ID
601335Gene Ontology
HyperlinkGene Summary
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq
Other Designations
JNK activating kinase 1|JNK-activated kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.
Kim HL, Vander Griend DJ, Yang X, Benson DA, Dubauskas Z, Yoshida BA, Chekmareva MA, Ichikawa Y, Sokoloff MH, Zhan P, Karrison T, Lin A, Stadler WM, Ichikawa T, Rubin MA, Rinker-Schaeffer CW.
Cancer Research 2001 Apr; 61(7):2833.
Application：IHC, WB-Ce, WB-Ti, Human, Rat, DUPro, Du145, TsuPr1, LNCaP,C4-2, PC-3, ASPC-1, MDA PCa2a, MDA PCa2b cells, Prostatic, Brain.
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Mitogen-activated protein kinase kinase 4 (MKK4).
Cuenda A.
The International Journal of Biochemistry & Cell Biology 2000 Jun; 32(6):581.
Application：WB, Human, Mammalian cells.
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The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product.
Crews CM, Alessandrini A, Erikson RL.
Science 1992 Oct; 258(5081):478.
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Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.
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