MAP2K4 recombinant monoclonal antibody, clone SEK1MKK4S257-C5
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More Files
- More Functions
Western Blot
Western blot analysis of THP1 cell extract, untreated or treated with sorbitol using phospho-SEK1/MKK4 (Ser257) antibody SEK1MKK4S257-C5 at 0.05 ug/mL.
Flow Cytometry
Flow cytometric analysis of HEK293T cells treated with lambda phosphatase (red) or treated with UV+TPA (green) using Phospho-SEK1/MKK4 (Ser257) (C5) Rabbit mAb, at 0.1 ug/mL, SEK1MKK4S257-C5, or concentration-matched Rabbit (G9) mAb IgG Isotype Control1 for cells treated with phosphatase (black) or treated with UV+TPA (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human MAP2K4.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser257 of human phospho SEK1/MKK4
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of THP1 cell extract, untreated or treated with sorbitol using phospho-SEK1/MKK4 (Ser257) antibody SEK1MKK4S257-C5 at 0.05 ug/mL.Flow Cytometry
Flow cytometric analysis of HEK293T cells treated with lambda phosphatase (red) or treated with UV+TPA (green) using Phospho-SEK1/MKK4 (Ser257) (C5) Rabbit mAb, at 0.1 ug/mL, SEK1MKK4S257-C5, or concentration-matched Rabbit (G9) mAb IgG Isotype Control1 for cells treated with phosphatase (black) or treated with UV+TPA (blue). -
Gene Info — MAP2K4
Entrez GeneID
6416Protein Accession#
P45985Gene Name
MAP2K4
Gene Alias
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SEK1, SERK1
Gene Description
mitogen-activated protein kinase kinase 4
Omim ID
601335Gene Ontology
HyperlinkGene Summary
This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq
Other Designations
JNK activating kinase 1|JNK-activated kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4
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Interactome
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Pathway
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Disease
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