ICAM1 monoclonal antibody, clone 15.2 (Biotin)
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Specification
Product Description
Mouse monoclonal antibody raised against native ICAM1.
Immunogen
A mixture of native ICAM1 from Rheumatoid synovial cells and human monocytes.
Host
Mouse
Reactivity
Human
Specificity
Recognizes the (Mr 85-115KDa) intercellular adhesion molecule ICAM-1 which permits antigen-independent adhesion between lymphocytes and their targets. The LFA-1 binding site is located in domain 1 of ICAM-1. ICAM-1 is a membrane glycoprotein with a wide tissue distribution that includes vascular endothelium and many cells of the immune system. CD54 is weakly expressed on resting peripheral blood lymphocytes. Upon activation by mitogens, the CD54 antigen is strongly expressed on B-cells, T-cells, macrophages and granulocytes. CD54 is the receptor for rhinoviruses and malaria
Form
Liquid
Conjugation
Biotin
Isotype
IgG1
Recommend Usage
Flow Cytometry (using 1ug to stain 1 x 106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS, pH 7.2 (1% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — ICAM1
Entrez GeneID
3383Gene Name
ICAM1
Gene Alias
BB2, CD54, P3.58
Gene Description
intercellular adhesion molecule 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq
Other Designations
cell surface glycoprotein P3.58|human rhinovirus receptor|intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.
Dransfield I, Cabanas C, Barrett J, Hogg N.
The Journal of Cell Biology 1992 Mar; 116(6):1527.
Application:Func, Human, Nematoda, JY cells, SKN cells, T cells.
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The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site.
Berendt AR, McDowall A, Craig AG, Bates PA, Sternberg MJ, Marsh K, Newbold CI, Hogg N.
Cell 1992 Jan; 68(1):71.
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Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.
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