This antibody recognizes all human endothelium tested. Preliminary evidence suggests that this antibody recognizes Thrombomodulin, but does not inhibit Thrombomodulin dependent activation of protein C.
Flow Cytometry (10ul of the suggested working dilution (neat) to label 106 cells in 100ul) Immunohistochemistry (Frozen sections) (1:10-1:100) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:10-1:50) The optimal working dilution should be determined by the end user.
In tissue culture supernatant (0.09% sodium azide)
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq