TNFRSF10C monoclonal antibody, clone TRAIL-R3-02 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant TNFRSF10C.
Immunogen
Recombinant Fc fusion protein corresponding to amino acids 1-280 of TNFRSF10C.
Host
Mouse
Theoretical MW (kDa)
35
Reactivity
Human
Specificity
This antibody reacts with TRAIL-R3, a 35 KDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Form
Liquid
Conjugation
PE
Concentration
0.1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — TNFRSF10C
Entrez GeneID
8794Gene Name
TNFRSF10C
Gene Alias
CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID
Gene Description
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Omim ID
603613Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq
Other Designations
TNF related TRAIL receptor|TNF related apoptosis-inducing ligand receptor 3|TRAIL receptor 3|antagonist decoy receptor for TRAIL/Apo-2L|decoy receptor 1|decoy without an intracellular domain|lymphocyte inhibitor of TRAIL|tumor necrosis factor receptor sup
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Interactome
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Disease
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Publication Reference
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Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
Merino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O.
Molecular and Cellular Biology 2006 Oct; 26(19):7046.
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Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.
Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK.
PNAS 2005 Dec; 102(50):18099.
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Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells.
Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S.
BMC Cancer 2005 May; 5:54.
Application:Flow Cyt, Human, MCF-7 cells.
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Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
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