TNFRSF10C monoclonal antibody, clone TR3.06
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human TNFRSF10C.
Immunogen
Recombinant protein corresponding to human TNFRSF10C (DcR1).
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
>95% (SDS-PAGE)
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (10% glycerol, 0.02% sodium azide).
Storage Instruction
For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Gene Info — TNFRSF10C
Entrez GeneID
8794Protein Accession#
O14798Gene Name
TNFRSF10C
Gene Alias
CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID
Gene Description
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Omim ID
603613Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq
Other Designations
TNF related TRAIL receptor|TNF related apoptosis-inducing ligand receptor 3|TRAIL receptor 3|antagonist decoy receptor for TRAIL/Apo-2L|decoy receptor 1|decoy without an intracellular domain|lymphocyte inhibitor of TRAIL|tumor necrosis factor receptor sup
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Interactome
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Pathway
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Disease
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