HLA-G monoclonal antibody, clone 01G (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against HLA-G.
Immunogen
HLA-B27 transgenic mice were imunized with H-2 identical murine cells transfected with and expressing genes encoding HLA-G and human beta2-microglobulin.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes membrane-bound form of HLA-G (full-length HLA-G1), but not soluble forms.
Form
Liquid
Conjugation
FITC
Concentration
1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — HLA-G
Entrez GeneID
3135Gene Name
HLA-G
Gene Alias
MHC-G
Gene Description
major histocompatibility complex, class I, G
Gene Ontology
HyperlinkGene Summary
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
Other Designations
HLA class I molecule|HLA-G histocompatibility antigen, class I, G|MHC class I antigen|OTTHUMP00000039485|b2 microglobulin
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Interactome
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Pathway
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Disease
- Abortion
- Anemia
- Arthritis
- Asthma
- Autoimmune Diseases
- Behcet Syndrome
- Birth Weight
- Bronchial Hyperreactivity
- Carcinoma
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Publication Reference
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Analysis of HLA-G expression in malignant hematopoetic cells from leukemia patients.
Polakova K, Krcova M, Kuba D, Russ G.
Leukemia Research 2003 Jul; 27(7):643.
Application:Flow Cyt, Human, Cells isolated from patients with acute myeloid leukemia (AML).
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Binding analysis of HLA-G specific antibodies to hematopoietic cells isolated from leukemia patients.
Poláková K, Bandzuchová E, Hofmeister V, Weiss EH, Hutter H, Russ G.
Neoplasma 2003 Mar; 50(5):331.
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Expression of the non-classical HLA-G antigen in tumor cell lines is extremely restricted.
Polakova K, Russ G.
Neoplasma 2000 Jan; 47(6):342.
Application:Flow Cyt, Human, JEG3 cells.
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Analysis of HLA-G expression in malignant hematopoetic cells from leukemia patients.
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