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Immunohistochemistry (Frozen sections)

Enzyme-linked Immunoabsorbent Assay

Functional Study

Analysis of cytolytical activity of human polyclonal NK cells on target melanoma cells. Blocking of HLA-G1 on transfectants with anti-human HLA-G (87G) restored specific lysis.
Target cells : M8 cell line transfected with empty vector (column 1) and with HLA-G1 cDNA (columns 2-6).
Blocking antibodies :
Column 1-2 : none.
Column 3 : Isotype mouse IgG2a control.
Column 4 : HLA-G monoclonal antibody, clone 87G (Cat # MAB11223).
Column 5 : HLA-G (Fab) monoclonal antibody, clone 87G.
Column 6 : HLA-G monoclonal antibody, clone MEM-G/9 (Cat # MAB3855).

Flow Cytometry

Entrez GeneID

3135

Gene Name

HLA-G

Gene Alias

MHC-G

Gene Description

major histocompatibility complex, class I, G

Omim ID

142871 600807

Gene Ontology

Hyperlink

Gene Summary

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq

Other Designations

HLA class I molecule|HLA-G histocompatibility antigen, class I, G|MHC class I antigen|OTTHUMP00000039485|b2 microglobulin