SPN monoclonal antibody, clone MEM-59 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native SPN.
Immunogen
Native purified SPN from human T lymphocytes.
Host
Mouse
Theoretical MW (kDa)
95-135
Reactivity
Human
Specificity
This antibody recognizes neuraminidase-sensitive epitope on CD43 (Leukosialin), a 95-135 KDa type I transmembrane glycoprotein (mucin-type) which is involved in lymphocyte activation.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — SPN
Entrez GeneID
6693Gene Name
SPN
Gene Alias
CD43, GPL115, LSN
Gene Description
sialophorin
Omim ID
182160Gene Ontology
HyperlinkGene Summary
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[supplied by OMIM
Other Designations
leukosialin|sialophorin (gpL115, leukosialin, CD43)|sialophorin (leukosialin, CD43)
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Interactome
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Pathway
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Disease
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Publication Reference
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Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
Simova S, Klima M, Cermak L, Sourkova V, Andera L.
Apoptosis 2008 Mar; 13(3):423.
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MEM-59 monoclonal antibody detects a CD43 epitope involved in lymphocyte activation.
Alvarado M, Klassen C, Cerny J, Horejsí V, Schmidt RE.
European Journal of Immunology 1995 Apr; 25(4):1051.
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Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.
Cermak L, Simova S, Pintzas A, Horejsi V, Andera L.
The Journal of Biological Chemistry 2001 Dec; 277(10):7955.
Application:Flow Cyt, Human, TF-1 cells.
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Characterization of a 95 kDa human leucocyte sialoglycoprotein: its identity with CD43, gpL115, leukosialin and sialophorin.
Stefanová I, Hilgert I, Angelisová P, Kristofová H, Horejsí V.
Folia Biol (Praha) 1988 Jan; 34(4):255.
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Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.
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