ITGA2B monoclonal antibody, clone MEM-06 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGA2B.
Immunogen
Native purified ITGA2B from leukocytes of a patient suffering from a LGL-type leukemia.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 KDa) and GPIIb beta (light chain; 23 KDa). CD41 is mainly expressed on platelets and megakaryocytes.
Form
Liquid
Conjugation
PE
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human platelets with ITGA2B monoclonal antibody, clone MEM-06 (PE) (Cat # MAB4431). -
Gene Info — ITGA2B
Entrez GeneID
3674Gene Name
ITGA2B
Gene Alias
CD41, CD41B, GP2B, GPIIb, GTA, HPA3
Gene Description
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene Ontology
HyperlinkGene Summary
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin alpha 2b|platelet fibrinogen receptor, alpha subunit|platelet-specific antigen BAK
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Interactome
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Pathway
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Publication Reference
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CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation.
Zhang J, Varas F, Stadtfeld M, Heck S, Faust N, Graf T.
Experimental Hematology 2007 Mar; 35(3):490.
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CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo.
Ferkowicz MJ, Starr M, Xie X, Li W, Johnson SA, Shelley WC, Morrison PR, Yoder MC.
Development 2003 Sep; 130(18):4393.
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Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells.
Mitjavila-Garcia MT, Cailleret M, Godin I, Nogueira MM, Cohen-Solal K, Schiavon V, Lecluse Y, Le Pesteur F, Lagrue AH, Vainchenker W.
Development 2002 Apr; 129(8):2003.
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CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation.
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