CD36 monoclonal antibody, clone TR9 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD36.
Immunogen
Native purified CD36 from human platelets.
Host
Mouse
Theoretical MW (kDa)
85
Reactivity
Human
Specificity
This antibody reacts with CD36 (GPIIIb), a 85 KDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. This antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5.
Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes to target cells).Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human platelets with CD36 monoclonal antibody, clone TR9 (FITC) (Cat # MAB4415). -
Gene Info — CD36
Entrez GeneID
948Gene Name
CD36
Gene Alias
CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
Gene Description
CD36 molecule (thrombospondin receptor)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
CD36 antigen|CD36 antigen (collagen type I receptor, thrombospondin receptor)|PAS-4 protein|cluster determinant 36|fatty acid translocase|glycoprotein IIIb|leukocyte differentiation antigen CD36|platelet glycoprotein IV|scavenger receptor class B, member
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Interactome
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Pathway
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Disease
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Publication Reference
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CD36 is differentially expressed on B cell subsets during development and in responses to antigen.
Won WJ, Bachmann MF, Kearney JF.
Journal of Immunology 2008 Jan; 180(1):230.
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The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse.
Gaillard D, Laugerette F, Darcel N, El-Yassimi A, Passilly-Degrace P, Hichami A, Khan NA, Montmayeur JP, Besnard P.
FASEB Journal 2007 Dec; 22(5):1458.
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Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4.
van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ.
Biochimica et Biophysica Acta 2007 Dec; 1781(1-2):61.
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CD36 is differentially expressed on B cell subsets during development and in responses to antigen.
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