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Flow Cytometry

5 X 10⁵ ficoll prepared human peripheral blood lymphocytes were washed and preincubated 5 minutes with 20 m l of 250 mg/mL human IgG (To block non specific binding) after which they were incubated 45 minutes on ice with 80m l of CD36 monoclonal antibody, clone SMO (Cat # MAB6908) at a concentration of 5 mg/mL. Cells were washed twice and incubated with Goat anti-Mouse Ig/FITC, after which they were washed three times, fixed and analyzed using a BD FACstar plus. A net 16% sub population of the cells stained positive with a mean shift of 1.05 log10 fluorescent units when compared to a Mouse IgM negative control at a similar concentration.

Entrez GeneID

948

Gene Name

CD36

Gene Alias

CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3

Gene Description

CD36 molecule (thrombospondin receptor)

Omim ID

173510 248310 608404 610938 611162

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq

Other Designations

CD36 antigen|CD36 antigen (collagen type I receptor, thrombospondin receptor)|PAS-4 protein|cluster determinant 36|fatty acid translocase|glycoprotein IIIb|leukocyte differentiation antigen CD36|platelet glycoprotein IV|scavenger receptor class B, member