IGF2R monoclonal antibody, clone MEM-238
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western Blotting analysis (non-reducing conditions) of IGF2R in whole cell lysate of Jurkat (human peripheral blood T cell leukemia cell line).
Lane 1 : Immunostaining with IGF2R monoclonal antibody, clone MEM-238 (Cat # MAB3860).
Lane 2 : Immunostaining with Isotype mouse IgG1 control.
-
Specification
Product Description
Mouse monoclonal antibody raised against recombinant IGF2R.
Immunogen
Recombinant protein corresponding to human IGF2R.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 KDa multifunctional type I transmembrane protein.The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% inthe plasma membrane and the truncated (220 KDa) form of CD222 is present in human and bovine serum.
Form
Liquid
Concentration
1 mg/mL
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western Blotting analysis (non-reducing conditions) of IGF2R in whole cell lysate of Jurkat (human peripheral blood T cell leukemia cell line).
Lane 1 : Immunostaining with IGF2R monoclonal antibody, clone MEM-238 (Cat # MAB3860).
Lane 2 : Immunostaining with Isotype mouse IgG1 control.Flow Cytometry
-
Gene Info — IGF2R
Entrez GeneID
3482Gene Name
IGF2R
Gene Alias
CD222, CIMPR, M6P-R, MPR1, MPRI
Gene Description
insulin-like growth factor 2 receptor
Omim ID
147280Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq
Other Designations
OTTHUMP00000017536|cation-independent mannose-6 phosphate receptor|insulin-like growth factor-2 receptor (mannose-6-phosphate receptor, cation-independent)
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation.
Wood RJ, Hulett MD.
The Journal of Biological Chemistry 2007 Dec; 283(7):4165.
Application：IP, PI, Mouse, MS9-II cells.
-
Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes.
Gasanov U, Koina C, Beagley KW, Aitken RJ, Hansbro PM.
Infection and Immunity 2006 Jan; 74(1):566.
Application：WB-Ce, Mouse, McCoy, MS9, MS9II cells.
-
TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen.
Leksa V, Godar S, Schiller HB, Fuertbauer E, Muhammad A, Slezakova K, Horejsi V, Steinlein P, Weidle UH, Binder BR, Stockinger H.
Journal of Cell Science 2005 Oct; 118(Pt 19):4577.
Application：Flow Cyt, IF, IP, WB, Human, HUVECs, HUVSMCs.
-
Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com