Mouse monoclonal antibody raised against recombinant IGF2R.
Recombinant protein corresponding to human IGF2R.
This antibody recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 KDa multifunctional type I transmembrane protein.The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% inthe plasma membrane and the truncated (220 KDa) form of CD222 is present in human and bovine serum.
The optimal working dilution should be determined by the end user.
In PBS, pH 7.4 (0.09% sodium azide)
Store at 4°C. Do not freeze. Avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Western Blotting analysis (non-reducing conditions) of IGF2R in whole cell lysate of Jurkat (human peripheral blood T cell leukemia cell line). Lane 1 : Immunostaining with IGF2R monoclonal antibody, clone MEM-238 (Cat # MAB3860). Lane 2 : Immunostaining with Isotype mouse IgG1 control.
The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. In mice, the homologous gene is expressed only from the maternal chromosome. [provided by RefSeq