HLA-G monoclonal antibody, clone MEM-G/11
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant HLA-G.
Immunogen
Recombinant protein corresponding to human HLA-G.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes HLA-G1 antigen. HLA-G belongs to the MHC Class Imolecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Surface staining of JEG-3 (human choriocarcinoma cell line) with HLA-G monoclonal antibody, clone MEM-G/11 (Cat # MAB3856) - FITC. Total viable cells were used for analysis. -
Gene Info — HLA-G
Entrez GeneID
3135Gene Name
HLA-G
Gene Alias
MHC-G
Gene Description
major histocompatibility complex, class I, G
Gene Ontology
HyperlinkGene Summary
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq
Other Designations
HLA class I molecule|HLA-G histocompatibility antigen, class I, G|MHC class I antigen|OTTHUMP00000039485|b2 microglobulin
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Interactome
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Pathway
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Disease
- Abortion
- Anemia
- Arthritis
- Asthma
- Autoimmune Diseases
- Behcet Syndrome
- Birth Weight
- Bronchial Hyperreactivity
- Carcinoma
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Publication Reference
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HLA-G expression in gastric carcinoma: clinicopathological correlations and prognostic impact.
Murdaca G, Calamaro P, Lantieri F, Pigozzi S, Mastracci L, Grillo F, Magnani O, Ceppa P, Puppo F, Fiocca R.
Virchows Archiv 2018 May; [Epub].
Application:IHC-P, Human, Gastric carcinoma.
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Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules.
Menier C, Saez B, Horejsi V, Martinozzi S, Krawice-Radanne I, Bruel S, Le Danff C, Reboul M, Hilgert I, Rabreau M, Larrad ML, Pla M, Carosella ED, Rouas-Freiss N.
Human Immunology 2003 Mar; 64(3):315.
Application:ELISA, Flow Cyt, WB, Human, LCL, JEG-3, K-562 cells.
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Disulfide bond-mediated dimerization of HLA-G on the cell surface.
Boyson JE, Erskine R, Whitman MC, Chiu M, Lau JM, Koopman LA, Valter MM, Angelisova P, Horejsi V, Strominger JL.
PNAS 2002 Dec; 99(25):16180.
Application:IHC-P, WB, Human, JAR, JEG-3 cells, Placental sections.
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HLA-G expression in gastric carcinoma: clinicopathological correlations and prognostic impact.
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