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Last updated: 2016/12/4
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SOS1 monoclonal antibody, clone SOS-01

  • Catalog # : MAB3649
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of SOS1.
  • Immunogen:
  • A synthetic peptide corresponding to human SOS1.
  • Sequence:
  • THPSMHRDGPPLLENAHSS
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 150
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • This antibody reacts with human SOS1, an ubiquitously expressed 150 KDa intracellular protein.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blotting analysis (reducing conditions) of human SOS1 using SOS1 monoclonal antibody, clone SOS-01 (Cat # MAB3649).
    Lane 1 : K-562 (human caucasian chronic myeloid leukemia cell line).
    Lane 2 : RAJI (human Burkitt lymphoma cell line).
  • Immunocytochemistry
  • Immunofluorescence
  • Immunofluorescence
  • Fig. A : Immunofluorescence staining of SOS1 in human primary fibroblasts using SOS1 monoclonal antibody, clone SOS-01 (Cat # MAB3649 ; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
    Fig. B : Immunofluorescence staining of SOS1 in murine transformed fibroblasts using SOS1 monoclonal antibody, clone SOS-01 (Cat # MAB3649 ; red). Actin cytoskeleton was decorated by phalloidin (green) and cell nuclei stained with DAPI (blue).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunocytochemistry
  • Gene Information
  • Entrez GeneID:
  • 6654
  • Gene Name:
  • SOS1
  • Gene Alias:
  • GF1,GGF1,GINGF,HGF,NS4
  • Gene Description:
  • son of sevenless homolog 1 (Drosophila)
  • Gene Summary:
  • This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000128306,gingival fibromatosis, hereditary, 1,guanine nucleotide exchange factor,son of sevenless homolog 1
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