Products

Western Blot (Cell lysate)

Western Blotting analysis (reducing conditions) of human SOS1 using SOS1 monoclonal antibody, clone SOS-01 (Cat # MAB3649).
Lane 1 : K-562 (human caucasian chronic myeloid leukemia cell line).
Lane 2 : RAJI (human Burkitt lymphoma cell line).

Immunocytochemistry

Immunofluorescence

Fig. A : Immunofluorescence staining of SOS1 in human primary fibroblasts using SOS1 monoclonal antibody, clone SOS-01 (Cat # MAB3649 ; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue).
Fig. B : Immunofluorescence staining of SOS1 in murine transformed fibroblasts using SOS1 monoclonal antibody, clone SOS-01 (Cat # MAB3649 ; red). Actin cytoskeleton was decorated by phalloidin (green) and cell nuclei stained with DAPI (blue).

Entrez GeneID

6654

Gene Name

SOS1

Gene Alias

GF1, GGF1, GINGF, HGF, NS4

Gene Description

son of sevenless homolog 1 (Drosophila)

Omim ID

135300 182530 610733

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq

Other Designations

OTTHUMP00000128306|gingival fibromatosis, hereditary, 1|guanine nucleotide exchange factor|son of sevenless homolog 1