ITGA2B monoclonal antibody, clone CA3
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Specification
Product Description
Mouse monoclonal antibody raised against native ITGA2B.
Immunogen
Native purified human ITGA2B.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with the alphaIIb-subunit of the beta-integrins. Reacts specifically with platelets, megakaryocytes and leukemic cells able to megakaryocytic differentiation. The alphaIIb-Integrin subunit is a specific marker for platelets and megakaryocytes and can be utilized for this purpose in various immunological techniques. Monoclonal antibody to alphaIIb integrin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (1% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
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Gene Info — ITGA2B
Entrez GeneID
3674Gene Name
ITGA2B
Gene Alias
CD41, CD41B, GP2B, GPIIb, GTA, HPA3
Gene Description
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene Ontology
HyperlinkGene Summary
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin alpha 2b|platelet fibrinogen receptor, alpha subunit|platelet-specific antigen BAK
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Interactome
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Pathway
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Disease
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Publication Reference
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Expression of megakaryocytic and erythroid properties in human leukemic cells.
Tani T, Ylänne J, Virtanen I.
Exp Hematol 1996 Feb; 24(2):158.
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Localization of beta 1, beta 3, alpha 5, alpha v, and alpha IIb subunits of the integrin family in spreading human erythroleukemia cells.
Ylanne J, Cheresh DA, Virtanen I.
Blood 1990 Aug; 76(3):570.
Application:IF, Human, HEL cells.
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Platelet glycoprotein IIb/IIIa complex in cultured cells. Localization in focal adhesion sites in spreading HEL cells.
Ylanne J, Hormia M, Jarvinen M, Vartio T, Virtanen I.
Blood 1988 Nov; 72(5):1478.
Application:IF, WB-Ce, Human, Large megakaryocytes, Fibroblasts, HUVECs, K-562 cells, HEL cells, Platelets.
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Expression of megakaryocytic and erythroid properties in human leukemic cells.
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