LMNA monoclonal antibody, clone JoL5
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against recombinant LMNA.
Immunogen
Recombinant protein corresponding to human LMNA.
Host
Mouse
Reactivity
Human, Mouse
Specificity
Detects an un-phosphorylated form of LMNA and the epitope is mapped to the N-terminal head domain of both proteins.
Form
Liquid
Isotype
IgG2
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:50)
Immunofluorescence (1:10)
The optimal working dilution should be determined by the end user.Storage Buffer
In tissue culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot using LMNA monoclonal antibody, clone JoL5 (Cat # MAB2502) showing extracts from mouse myoblasts C2C12. Upper band is LMNA and the lower is LMNC.Immunofluorescence
-
Gene Info — LMNA
Entrez GeneID
4000Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine.
Pabst O, Ohl L, Wendland M, Wurbel MA, Kremmer E, Malissen B, Förster R.
The Journal of Experimental Medicine 2004 Feb; 199(3):411.
-
Cell cycle changes in A-type lamin associations detected in human dermal fibroblasts using monoclonal antibodies.
Dyer JA, Kill IR, Pugh G, Quinlan RA, Lane EB, Hutchison CJ.
Chromosome Research 1997 Sep; 5(6):383.
Application:IF, WB-Ce, Human, Human dermal fibroblasts.
-
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com