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Last updated: 2016/10/23
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LMNA monoclonal antibody, clone JoL5

  • Catalog # : MAB2502
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant LMNA.
  • Immunogen:
  • Recombinant protein corresponding to human LMNA.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • Detects an un-phosphorylated form of LMNA and the epitope is mapped to the N-terminal head domain of both proteins.
  • Form:
  • Liquid
  • Isotype:
  • IgG2
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (1:50)
    Immunofluorescence (1:10)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In tissue culture supernatant (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot using LMNA monoclonal antibody, clone JoL5 (Cat # MAB2502) showing extracts from mouse myoblasts C2C12. Upper band is LMNA and the lower is LMNC.
  • Immunofluorescence
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 4000
  • Gene Name:
  • LMNA
  • Gene Alias:
  • Gene Description:
  • lamin A/C
  • Gene Summary:
  • The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
  • Other Designations:
  • 70 kDa lamin,OTTHUMP00000015843,OTTHUMP00000015848
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