LMNA recombinant monoclonal antibody, clone LaminACS22-CF12
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More Files
- More Functions
Western Blot
Western blot analysis of HeLa cell extract untreated or treated with nocodazole using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 10 ng/mL.
Flow Cytometry
Flow cytometric analysis of HeLa cells untreated (red) or treated (green) using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 0.01 ug/mL or concentration matched isotope control for untreated (grey) or treated with nocodazole (orange) isotype control, or negative control (blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human LMNA.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser22 of human phospho Lamin A/C
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of HeLa cell extract untreated or treated with nocodazole using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 10 ng/mL.Flow Cytometry
Flow cytometric analysis of HeLa cells untreated (red) or treated (green) using Phospho-Lamin A/C (Ser22) antibody LaminACS22-CF12 at 0.01 ug/mL or concentration matched isotope control for untreated (grey) or treated with nocodazole (orange) isotype control, or negative control (blue). -
Gene Info — LMNA
Entrez GeneID
4000Protein Accession#
P02545Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
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Interactome
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Pathway
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Disease
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