JAK3 (phospho Y980/981) monoclonal antibody, clone E10
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic phosphopeptide of human JAK3.
Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Y980/981 of human Jak3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.1% BSA and 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of COS7 cell lysate with JAK3 (phospho Y980/981) monoclonal antibody, clone CF12 (Cat # MAB23565). Lane 1: untreated or Lane 2: treated with pervanadate.Flow Cytometry
Flow cytometric analysis of Ramos cells with JAK3 (phospho Y980/981) monoclonal antibody, clone E10 (Cat # MAB23565). Secondary antibody only negative control (blue) or untreated (red) or treated with pervanadate (green). -
Gene Info — JAK3
Entrez GeneID
3718Protein Accession#
P52333Gene Name
JAK3
Gene Alias
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Gene Description
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
Omim ID
600173Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq
Other Designations
Janus kinase 3|leukocyte Janus kinase|tyrosine-protein kinase JAK3
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